Louis Philipson

Biosciences Graduate Program Association
  1. Acute Recurrent Pancreatitis in a Child With INS-Related Monogenic Diabetes and a Heterozygous Pathogenic CFTR Mutation. J Endocr Soc. 2023 Jan 06; 7(3):bvac182. View in: PubMed

  2. Objective and Subjective Sleep Patterns in Adults With Maturity-Onset Diabetes of the Young (MODY). Diabetes Care. 2023 03 01; 46(3):608-612. View in: PubMed

  3. Insight on Diagnosis and Treatment From Over a Decade of Research Through the University of Chicago Monogenic Diabetes Registry. Front Clin Diabetes Healthc. 2021 Nov; 2. View in: PubMed

  4. First-Line Therapy for Type 2 Diabetes With Sodium-Glucose Cotransporter-2 Inhibitors and Glucagon-Like Peptide-1 Receptor Agonists : A Cost-Effectiveness Study. Ann Intern Med. 2022 10; 175(10):1392-1400. View in: PubMed

  5. Precision diabetes: Lessons learned from maturity-onset diabetes of the young (MODY). J Diabetes Investig. 2022 Sep; 13(9):1465-1471. View in: PubMed

  6. Benefit of Continuous Glucose Monitoring in Reducing Hypoglycemia Is Sustained Through 12 Months of Use Among Older Adults with Type 1 Diabetes. Diabetes Technol Ther. 2022 06; 24(6):424-434. View in: PubMed

  7. Islets Transplantation at a Crossroads - Need for Urgent Regulatory Update in the United States: Perspective Presented During the Scientific Sessions 2021 at the American Diabetes Association Congress. Front Endocrinol (Lausanne). 2021; 12:789526. View in: PubMed

  8. ADA/EASD Precision Medicine in Diabetes Initiative: An International Perspective and Future Vision for Precision Medicine in Diabetes. Diabetes Care. 2022 02 01; 45(2):261-266. View in: PubMed

  9. 307.5: Modified Approach Allowed for Improved Islet Allotransplantation Into Pre-vascularized Sernova Cell PouchTM Device - Preliminary Results of the Phase I/II Clinical Trial at University of Chicago. Transplantation. 2021 Dec 01; 105(12 Suppl 1):S25. View in: PubMed

  10. Integrated Analysis of the Pancreas and Islets Reveals Unexpected Findings in Human Male With Type 1 Diabetes. J Endocr Soc. 2021 Dec 01; 5(12):bvab162. View in: PubMed

  11. Longer-term Benefits and Risks of Sodium-Glucose Cotransporter-2 Inhibitors in Type 2 Diabetes: a Systematic Review and Meta-analysis. J Gen Intern Med. 2022 02; 37(2):439-448. View in: PubMed

  12. Developmental defects and impaired network excitability in a cerebral organoid?model of?KCNJ11 p.V59M-related neonatal diabetes. Sci Rep. 2021 11 03; 11(1):21590. View in: PubMed

  13. The Longer-Term Benefits and Harms of Glucagon-Like Peptide-1 Receptor Agonists: a Systematic Review and Meta-Analysis. J Gen Intern Med. 2022 02; 37(2):415-438. View in: PubMed

  14. Diabetes With Multiple Autoimmune and Inflammatory Conditions Linked to an Activating SKAP2 Mutation. Diabetes Care. 2021 08; 44(8):1816-1825. View in: PubMed

  15. Transparent, Compliant 3D Mesostructures for Precise Evaluation of Mechanical Characteristics of Organoids. Adv Mater. 2021 Jun; 33(25):e2100026. View in: PubMed

  16. Post-Hoc Analysis of a Randomized, Double Blind, Prospective Study at the University of Chicago: Additional Standardizations of Trial Protocol are Needed to Evaluate the Effect of a CXCR1/2 Inhibitor in Islet Allotransplantation. Cell Transplant. 2021 Jan-Dec; 30:9636897211001774. View in: PubMed

  17. Monogenic Diabetes: From Genetic Insights to Population-Based Precision in Care. Reflections From a Diabetes Care Editors' Expert Forum. Diabetes Care. 2020 12; 43(12):3117-3128. View in: PubMed

  18. The demise of islet allotransplantation in the United States: A call for an urgent regulatory update. Am J Transplant. 2021 04; 21(4):1365-1375. View in: PubMed

  19. Approach to the Patient with MODY-Monogenic Diabetes. J Clin Endocrinol Metab. 2021 01 01; 106(1):237-250. View in: PubMed

  20. Exenatide extended release in patients with type 1 diabetes with and without residual insulin production. Diabetes Obes Metab. 2020 11; 22(11):2045-2054. View in: PubMed

  21. Precision Medicine in Diabetes: A Consensus Report From the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2020 07; 43(7):1617-1635. View in: PubMed

  22. Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2020 09; 63(9):1671-1693. View in: PubMed

  23. Effect of Continuous Glucose Monitoring on Hypoglycemia in Older Adults With Type 1 Diabetes: A Randomized Clinical Trial. JAMA. 2020 06 16; 323(23):2397-2406. View in: PubMed

  24. Integrated Pancreatic Blood Flow: Bidirectional Microcirculation Between Endocrine and Exocrine Pancreas. Diabetes. 2020 07; 69(7):1439-1450. View in: PubMed

  25. Harnessing heterogeneity in type 2 diabetes mellitus. Nat Rev Endocrinol. 2020 02; 16(2):79-80. View in: PubMed

  26. Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2). Diabetes. 2019 08; 68(8):1565-1576. View in: PubMed

  27. GCK-MODY in the US Monogenic Diabetes Registry: Description of 27 unpublished variants. Diabetes Res Clin Pract. 2019 May; 151:231-236. View in: PubMed

  28. Management and pregnancy outcomes of women with GCK-MODY enrolled in the US Monogenic Diabetes Registry. Acta Diabetol. 2019 Apr; 56(4):405-411. View in: PubMed

  29. Human islets expressing HNF1A variant have defective ? cell transcriptional regulatory networks. J Clin Invest. 2019 01 02; 129(1):246-251. View in: PubMed

  30. Multi-level Supervision and Modification of Artificial Pancreas Control System. Comput Chem Eng. 2018 Apr 06; 112:57-69. View in: PubMed

  31. Response to Jentsch et?al. Cell Metab. 2010 Oct 06; 12(4):310. View in: PubMed

  32. Monogenic Diabetes in Children and Adolescents: Recognition and Treatment Options. Curr Diab Rep. 2018 06 22; 18(8):58. View in: PubMed

  33. Precision medicine in KCNJ11 permanent neonatal diabetes. Lancet Diabetes Endocrinol. 2018 08; 6(8):594-595. View in: PubMed

  34. a Cell Function and Gene Expression Are Compromised in Type 1 Diabetes. Cell Rep. 2018 03 06; 22(10):2667-2676. View in: PubMed

  35. Early Intensive Insulin Use May Preserve ?-Cell Function in Neonatal Diabetes Due to Mutations in the Proinsulin Gene. J Endocr Soc. 2018 Jan 01; 2(1):1-8. View in: PubMed

  36. Comparative evaluation of simple indices using a single fasting blood sample to estimate beta cell function after islet transplantation. Am J Transplant. 2018 04; 18(4):990-997. View in: PubMed

  37. External Validation of the Newly Developed BETA-2 Scoring System for Pancreatic Islet Graft Function Assessment. Transplant Proc. 2017 Dec; 49(10):2340-2346. View in: PubMed

  38. Pain Control, Glucose Control, and Quality of Life in Patients With Chronic Pancreatitis After Total Pancreatectomy With Islet Autotransplantation: A Preliminary Report. Transplant Proc. 2017 Dec; 49(10):2333-2339. View in: PubMed

  39. FOXP3 mutations causing early-onset insulin-requiring diabetes but without other features of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Pediatr Diabetes. 2018 05; 19(3):388-392. View in: PubMed

  40. Simultaneous Real-Time Measurement of the ?-Cell Membrane Potential and Ca2+ Influx to Assess the Role of Potassium Channels on ?-Cell Function. Methods Mol Biol. 2018; 1684:73-84. View in: PubMed

  41. Deletion of Protein Kinase D1 in Pancreatic ?-Cells Impairs Insulin Secretion in High-Fat Diet-Fed Mice. Diabetes. 2018 01; 67(1):71-77. View in: PubMed

  42. Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA. J Clin Endocrinol Metab. 2018 01 01; 103(1):35-45. View in: PubMed

  43. Diabetes Presentation in Infancy: High Risk of Diabetic Ketoacidosis. Diabetes Care. 2017 10; 40(10):e147-e148. View in: PubMed

  44. Correlative imaging across microscopy platforms using the fast and accurate relocation of microscopic experimental regions (FARMER) method. Rev Sci Instrum. 2017 May; 88(5):053702. View in: PubMed

  45. Preservation of Reduced Numbers of Insulin-Positive Cells in Sulfonylurea-Unresponsive KCNJ11-Related Diabetes. J Clin Endocrinol Metab. 2017 01 01; 102(1):1-5. View in: PubMed

  46. Outcomes of Pancreatic Islet Allotransplantation Using the Edmonton Protocol at the University of Chicago. Transplant Direct. 2016 Oct; 2(10):e105. View in: PubMed

  47. Growth Hormone-Releasing Hormone in Diabetes. Front Endocrinol (Lausanne). 2016; 7:129. View in: PubMed

  48. Patients with KCNJ11-related diabetes frequently have neuropsychological impairments compared with sibling controls. Diabet Med. 2016 10; 33(10):1380-6. View in: PubMed

  49. The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions. Diabetes. 2016 09; 65(9):2711-23. View in: PubMed

  50. Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis. PLoS One. 2016; 11(5):e0152869. View in: PubMed

  51. GCK-MODY in the US National Monogenic Diabetes Registry: frequently misdiagnosed and unnecessarily treated. Acta Diabetol. 2016 Oct; 53(5):703-8. View in: PubMed

  52. A Transient Metabolic Recovery from Early Life Glucose Intolerance in Cystic Fibrosis Ferrets Occurs During Pancreatic Remodeling. Endocrinology. 2016 05; 157(5):1852-65. View in: PubMed

  53. Resting beta-cells?-?A functional reserve? Diabetes Metab. 2016 Jun; 42(3):157-61. View in: PubMed

  54. TCF1 links GIPR signaling to the control of beta cell function and survival. Nat Med. 2016 Jan; 22(1):84-90. View in: PubMed

  55. PGC-1 coactivators in ?-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids. Mol Metab. 2015 Nov; 4(11):811-22. View in: PubMed

  56. Metastatic Insulinoma Following Resection of Nonsecreting Pancreatic Islet Cell Tumor: A Case Report and Review of the Literature. J Investig Med High Impact Case Rep. 2013 Jan-Mar; 1(1):2324709612473274. View in: PubMed

  57. Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis. J Clin Invest. 2015 Nov 02; 125(11):4026-41. View in: PubMed

  58. An online monogenic diabetes discussion group: supporting families and fueling new research. Transl Res. 2015 Nov; 166(5):425-31. View in: PubMed

  59. Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects. J Biol Chem. 2015 Aug 21; 290(34):20934-20946. View in: PubMed

  60. Continued lessons from the INS gene: an intronic mutation causing diabetes through a novel mechanism. J Med Genet. 2015 Sep; 52(9):612-6. View in: PubMed

  61. Insulin dosing in pediatric diabetic ketoacidosis: where to start? JAMA. 2015 Jun 09; 313(22):2274-5. View in: PubMed

  62. Role of noninsulin therapies alone or in combination in chromosome 6q24-related transient neonatal diabetes: sulfonylurea improves but does not always normalize insulin secretion. Diabetes Care. 2015 Jun; 38(6):e86-7. View in: PubMed

  63. Age at the time of sulfonylurea initiation influences treatment outcomes in KCNJ11-related neonatal diabetes. Diabetologia. 2015 Jul; 58(7):1430-5. View in: PubMed

  64. Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic ?-cells via protein kinase A. Mol Metab. 2015 Apr; 4(4):265-76. View in: PubMed

  65. A review of the mental health issues of diabetes conference. Diabetes Care. 2015 Feb; 38(2):333-8. View in: PubMed

  66. Donald F. Steiner MD, 1930-2014: discoverer of proinsulin. Proc Natl Acad Sci U S A. 2015 Jan 27; 112(4):940-1. View in: PubMed

  67. Routine depression screening for patients with diabetes--reply. JAMA. 2014 Dec 10; 312(22):2413. View in: PubMed

  68. Update on diabetes classification. Med Clin North Am. 2015 Jan; 99(1):1-16. View in: PubMed

  69. Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state. Endocrinology. 2015 Feb; 156(2):444-52. View in: PubMed

  70. The gene for staphylococcal protein A. Immunol Today. 1984 Aug; 5(8):244-8. View in: PubMed

  71. Sulfonylurea treatment before genetic testing in neonatal diabetes: pros and cons. J Clin Endocrinol Metab. 2014 Dec; 99(12):E2709-14. View in: PubMed

  72. The mental health comorbidities of diabetes. JAMA. 2014 Aug 20; 312(7):691-2. View in: PubMed

  73. Transgenic zebrafish model of the C43G human insulin gene mutation. J Diabetes Investig. 2013 Mar 18; 4(2):157-67. View in: PubMed

  74. Genetics and pathophysiology of neonatal diabetes mellitus. J Diabetes Investig. 2011 Jun 05; 2(3):158-69. View in: PubMed

  75. Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic ? cells. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):E2319-28. View in: PubMed

  76. The role of ? cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs. Cell Metab. 2014 Jun 03; 19(6):1050-7. View in: PubMed

  77. Neonatal diabetes: the brain comes into focus. Lancet Diabetes Endocrinol. 2013 Nov; 1(3):167-8. View in: PubMed

  78. Quantifying insulin sensitivity and entero-insular responsiveness to hyper- and hypoglycemia in ferrets. PLoS One. 2014; 9(3):e90519. View in: PubMed

  79. Lean versus obese diabetes mellitus patients in the United States minority population. J Diabetes Complications. 2014 Jul-Aug; 28(4):500-5. View in: PubMed

  80. Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in ? cells. Cell Metab. 2014 Jan 07; 19(1):109-21. View in: PubMed

  81. Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin. Genetics. 2014 Feb; 196(2):539-55. View in: PubMed

  82. Distribution of directional change as a signature of complex dynamics. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):19689-94. View in: PubMed

  83. Microcephaly, epilepsy, and neonatal diabetes due to compound heterozygous mutations in IER3IP1: insights into the natural history of a rare disorder. Pediatr Diabetes. 2014 May; 15(3):252-6. View in: PubMed

  84. Cost-effectiveness of MODY genetic testing: translating genomic advances into practical health applications. Diabetes Care. 2014; 37(1):202-9. View in: PubMed

  85. Ion channels and regulation of insulin secretion in human ?-cells: a computational systems analysis. Islets. 2013 Jan-Feb; 5(1):1-15. View in: PubMed

  86. Intracellular transport of insulin granules is a subordinated random walk. Proc Natl Acad Sci U S A. 2013 Mar 26; 110(13):4911-6. View in: PubMed

  87. Genome wide association studies for diabetes: perspective on results and challenges. Pediatr Diabetes. 2013 Mar; 14(2):90-6. View in: PubMed

  88. ?-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion. Diabetes. 2013 May; 62(5):1527-36. View in: PubMed

  89. A computational systems analysis of factors regulating a cell glucagon secretion. Islets. 2012 Jul-Aug; 4(4):262-83. View in: PubMed

  90. SUMO downregulates GLP-1-stimulated cAMP generation and insulin secretion. Am J Physiol Endocrinol Metab. 2012 Mar 15; 302(6):E714-23. View in: PubMed

  91. Neonatal diabetes: an expanding list of genes allows for improved diagnosis and treatment. Curr Diab Rep. 2011 Dec; 11(6):519-32. View in: PubMed

  92. Coupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysis. Prog Biophys Mol Biol. 2011 Nov; 107(2):293-303. View in: PubMed

  93. Creation of the Web-based University of Chicago Monogenic Diabetes Registry: using technology to facilitate longitudinal study of rare subtypes of diabetes. J Diabetes Sci Technol. 2011 Jul 01; 5(4):879-86. View in: PubMed

  94. Who should have genetic testing for maturity-onset diabetes of the young? Clin Endocrinol (Oxf). 2011 Oct; 75(4):422-6. View in: PubMed

  95. The cost-effectiveness of personalized genetic medicine: the case of genetic testing in neonatal diabetes. Diabetes Care. 2011 Mar; 34(3):622-7. View in: PubMed

  96. Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene. Rev Endocr Metab Disord. 2010 Sep; 11(3):205-15. View in: PubMed

  97. Intraperitoneal injection into adult zebrafish. J Vis Exp. 2010 Aug 30; (42). View in: PubMed

  98. Conditional gene targeting in mouse pancreatic ?-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes. 2010 Dec; 59(12):3090-8. View in: PubMed

  99. Glucose-induced ERM protein activation and translocation regulates insulin secretion. Am J Physiol Endocrinol Metab. 2010 Nov; 299(5):E772-85. View in: PubMed

  100. Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses. J Physiol. 2010 Sep 15; 588(Pt 18):3525-37. View in: PubMed

  101. Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms. Am J Physiol Endocrinol Metab. 2010 Oct; 299(4):E517-32. View in: PubMed

  102. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature. 2010 Jul 29; 466(7306):627-31. View in: PubMed

  103. Blood sugar measurement in zebrafish reveals dynamics of glucose homeostasis. Zebrafish. 2010 Jun; 7(2):205-13. View in: PubMed

  104. Glucose sensing in the pancreatic beta cell: a computational systems analysis. Theor Biol Med Model. 2010 May 24; 7:15. View in: PubMed

  105. Neonatal diabetes mellitus: a model for personalized medicine. Trends Endocrinol Metab. 2010 Aug; 21(8):464-72. View in: PubMed

  106. Update in neonatal diabetes. Curr Opin Endocrinol Diabetes Obes. 2010 Feb; 17(1):13-9. View in: PubMed

  107. In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes. Am J Physiol Endocrinol Metab. 2010 Mar; 298(3):E403-10. View in: PubMed

  108. A brief perspective on insulin production. Diabetes Obes Metab. 2009 Nov; 11 Suppl 4:189-96. View in: PubMed

  109. The granular chloride channel ClC-3 is permissive for insulin secretion. Cell Metab. 2009 Oct; 10(4):316-23. View in: PubMed

  110. A nanoporous, transparent microcontainer for encapsulated islet therapy. J Diabetes Sci Technol. 2009 Mar; 3(2):297-303. View in: PubMed

  111. Tooth discoloration in patients with neonatal diabetes after transfer onto glibenclamide: a previously unreported side effect. Diabetes Care. 2009 Aug; 32(8):1428-30. View in: PubMed

  112. A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cells. Biophys J. 2009 Apr 22; 96(8):3126-39. View in: PubMed

  113. Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. Mol Cell Biol. 2009 Jun; 29(11):3151-62. View in: PubMed

  114. The alpha-cell conundrum: ATP-sensitive K+ channels and glucose sensing. Diabetes. 2009 Feb; 58(2):304-6. View in: PubMed

  115. The chemistrode: a droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):16843-8. View in: PubMed

  116. Diagnosis and treatment of neonatal diabetes: a United States experience. Pediatr Diabetes. 2008 Oct; 9(5):450-9. View in: PubMed

  117. Reversible translocation of EYFP-tagged STIM1 is coupled to calcium influx in insulin secreting beta-cells. Cell Calcium. 2008 Dec; 44(6):533-44. View in: PubMed

  118. When BAD is good for beta cells. Cell Metab. 2008 Apr; 7(4):280-1. View in: PubMed

  119. The coxsackievirus and adenovirus receptor. Curr Top Microbiol Immunol. 2008; 323:67-87. View in: PubMed

  120. Reactive species, cellular repair and risk factors in the onset of type 2 diabetes mellitus: review and hypothesis. Curr Diabetes Rev. 2006 May; 2(2):241-59. View in: PubMed

  121. Single particle image reconstruction of the human recombinant Kv2.1 channel. Biophys J. 2008 Mar 15; 94(6):2106-14. View in: PubMed

  122. Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes. Diabetes. 2008 Apr; 57(4):1131-5. View in: PubMed

  123. Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood. Diabetes. 2008 Apr; 57(4):1034-42. View in: PubMed

  124. Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach. Am J Physiol Cell Physiol. 2007 Dec; 293(6):C1924-33. View in: PubMed

  125. Action potentials and insulin secretion: new insights into the role of Kv channels. Diabetes Obes Metab. 2007 Nov; 9 Suppl 2:89-98. View in: PubMed

  126. Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice. Am J Physiol Endocrinol Metab. 2008 Feb; 294(2):E217-29. View in: PubMed

  127. Insulin gene mutations as a cause of permanent neonatal diabetes. Proc Natl Acad Sci U S A. 2007 Sep 18; 104(38):15040-4. View in: PubMed

  128. Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion. Cell Metab. 2007 Sep; 6(3):229-35. View in: PubMed

  129. Ethics of hematopoietic stem cell transplantation in type 1 diabetes mellitus. JAMA. 2007 Jul 18; 298(3):285; author reply 285-6. View in: PubMed

  130. Protective role for nitric oxide during the endoplasmic reticulum stress response in pancreatic beta-cells. Am J Physiol Endocrinol Metab. 2007 Jun; 292(6):E1543-54. View in: PubMed

  131. TRP channels of the pancreatic beta cell. Handb Exp Pharmacol. 2007; (179):409-24. View in: PubMed

  132. Modulation of the pancreatic islet beta-cell-delayed rectifier potassium channel Kv2.1 by the polyunsaturated fatty acid arachidonate. J Biol Chem. 2007 Mar 09; 282(10):7442-9. View in: PubMed

  133. Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen. Diabetes. 2006 Dec; 55(12):3256-63. View in: PubMed

  134. Improved outcomes in islet isolation and transplantation by the use of a novel hemoglobin-based O2 carrier. Am J Transplant. 2006 Dec; 6(12):2861-70. View in: PubMed

  135. Cold climate genes and the prevalence of type 2 diabetes mellitus. Med Hypotheses. 2006; 67(5):1034-41. View in: PubMed

  136. Visualizing calcium signaling in cells by digitized wide-field and confocal fluorescent microscopy. Methods Mol Biol. 2006; 319:37-66. View in: PubMed

  137. Functional MR microimaging of pancreatic beta-cell activation. Cell Transplant. 2006; 15(2):195-203. View in: PubMed

  138. Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression. Am J Physiol Endocrinol Metab. 2006 Sep; 291(3):E587-95. View in: PubMed

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  142. Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration. Science. 2006 Mar 24; 311(5768):1774-5. View in: PubMed

  143. Oxidative reactive species in cell injury: Mechanisms in diabetes mellitus and therapeutic approaches. Ann N Y Acad Sci. 2005 Dec; 1066:136-51. View in: PubMed

  144. Reactive species and early manifestation of insulin resistance in type 2 diabetes. Diabetes Obes Metab. 2006 Mar; 8(2):136-45. View in: PubMed

  145. Inositol (1,4,5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells. Diabetes. 2005 Nov; 54(11):3073-81. View in: PubMed

  146. Delayed-rectifier (KV2.1) regulation of pancreatic beta-cell calcium responses to glucose: inhibitor specificity and modeling. Am J Physiol Endocrinol Metab. 2005 Oct; 289(4):E578-85. View in: PubMed

  147. Adenine nucleotide regulation in pancreatic beta-cells: modeling of ATP/ADP-Ca2+ interactions. Am J Physiol Endocrinol Metab. 2005 Nov; 289(5):E839-48. View in: PubMed

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  149. Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells. J Endocrinol. 2005 Apr; 185(1):57-67. View in: PubMed

  150. FRET-based voltage probes for confocal imaging: membrane potential oscillations throughout pancreatic islets. Am J Physiol Cell Physiol. 2005 Jul; 289(1):C224-9. View in: PubMed

  151. Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells? Diabetes. 2004 Aug; 53(8):1942-8. View in: PubMed

  152. Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9266-71. View in: PubMed

  153. Islet isolation under cGMP conditions: replacing the coil. Transplant Proc. 2004 May; 36(4):1031-3. View in: PubMed

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  163. Small-conductance calcium-activated K+ channels are expressed in pancreatic islets and regulate glucose responses. Diabetes. 2003 Aug; 52(8):2000-6. View in: PubMed

  164. Mutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1). Proc Natl Acad Sci U S A. 2003 May 13; 100(10):5622-7. View in: PubMed

  165. Modeling of Ca2+ flux in pancreatic beta-cells: role of the plasma membrane and intracellular stores. Am J Physiol Endocrinol Metab. 2003 Jul; 285(1):E138-54. View in: PubMed

  166. Visualizing superoxide production in normal and diabetic rat islets of Langerhans. J Biol Chem. 2003 Mar 14; 278(11):9796-801. View in: PubMed

  167. Insulin secretory deficiency and glucose intolerance in Rab3A null mice. J Biol Chem. 2003 Mar 14; 278(11):9715-21. View in: PubMed

  168. beta-Agonists and metabolism. J Allergy Clin Immunol. 2002 Dec; 110(6 Suppl):S313-7. View in: PubMed

  169. Human urinary bladder carcinomas express adenovirus attachment and internalization receptors. Gene Ther. 2002 May; 9(9):547-53. View in: PubMed

  170. TRP genes: candidates for nonselective cation channels and store-operated channels in insulin-secreting cells. Diabetes. 2002 Feb; 51 Suppl 1:S183-9. View in: PubMed

  171. Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism. Diabetes. 2001 Nov; 50(11):2472-80. View in: PubMed

  172. A mouse model for adenovirus gene delivery. Proc Natl Acad Sci U S A. 2001 Jul 03; 98(14):7910-5. View in: PubMed

  173. Baculovirus-mediated gene transfer into pancreatic islet cells. Diabetes. 2000 Dec; 49(12):1986-91. View in: PubMed

  174. The status of voltage-dependent calcium channels in alpha 1E knock-out mice. J Neurosci. 2000 Dec 01; 20(23):8566-71. View in: PubMed

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