Dr. Mutlu is Professor of Medicine and Chief of the Section of Pulmonary and Critical Care Medicine at the University of Chicago. He is also the principal investigator/director of the NIH T32 Research training in respiratory biology. Dr. Mutlu's research focuses on the mechanisms of acute lung injury, and pulmonary fibrosis. Specifically, his laboratory is interested in understanding the role of macrophage and fibroblast metabolism including mitochondria in the pathogenesis of acute lung injury and pulmonary fibrosis. Dr. Mutlu's laboratory has extensive expertise with in vitro cell based methods including bioenergetics and in vivo models of acute lung injury (influenza, LPS, bacterial pneumonia and particulate matter) and pulmonary fibrosis (bleomycin).
Air Pollution Within the Public Health Exposome Framework: Impacts on Cardiovascular Health.
Air Pollution Within the Public Health Exposome Framework: Impacts on Cardiovascular Health. Curr Epidemiol Rep. 2026; 13(1):13.
PMID: 42058949
Cross-tissue molecular responses in the liver and blood after toxicant exposures.
Cross-tissue molecular responses in the liver and blood after toxicant exposures. Res Sq. 2025 Oct 10.
PMID: 41282178
Plasticity of Epigenomic and Transcriptomic Aging Reveals Common Targets for Reprogramming by Environmental Exposures.
Plasticity of Epigenomic and Transcriptomic Aging Reveals Common Targets for Reprogramming by Environmental Exposures. Res Sq. 2025 Sep 19.
PMID: 41001535
HIF-1 regulates mitochondrial function in bone marrow-derived macrophages but not in tissue-resident alveolar macrophages.
HIF-1 regulates mitochondrial function in bone marrow-derived macrophages but not in tissue-resident alveolar macrophages. Sci Rep. 2025 Apr 04; 15(1):11574.
PMID: 40185846
Precision mRNA Nanomedicine for Targeted Vascular Therapies in ARDS and Atherosclerosis.
Precision mRNA Nanomedicine for Targeted Vascular Therapies in ARDS and Atherosclerosis. bioRxiv. 2025 Jan 14.
PMID: 41573922
Geotrichum infection in an immunocompetent host with SARS-CoV-2 infection.
Geotrichum infection in an immunocompetent host with SARS-CoV-2 infection. Tuberk Toraks. 2021 Sep; 69(3):421-424.
PMID: 34581166
SARS-CoV-2 Infection Is Associated with Reduced Krüppel-like Factor 2 in Human Lung Autopsy.
SARS-CoV-2 Infection Is Associated with Reduced Krüppel-like Factor 2 in Human Lung Autopsy. Am J Respir Cell Mol Biol. 2021 08; 65(2):222-226.
PMID: 33971111
Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release.
Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release. Front Physiol. 2021; 12:701995.
PMID: 34322038
Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells.
Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells. Nat Metab. 2021 05; 3(5):714-727.
PMID: 34031595
The role of metabolic reprogramming and de novo amino acid synthesis in collagen protein production by myofibroblasts: implications for organ fibrosis and cancer.
The role of metabolic reprogramming and de novo amino acid synthesis in collagen protein production by myofibroblasts: implications for organ fibrosis and cancer. Amino Acids. 2021 Dec; 53(12):1851-1862.
PMID: 33963932