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Bruce Bissonnette

Associate Professor
bis3@uchicago.edu
Research Summary
Brief Summary of Clinical activities: General gastroenterology. Diagnosis, management, and where appropriate, triage of patients with gastrointestinal disorders, including abdominal pain, GI bleeding, iron deficiency anemia, diarrhea, constipation, malabsorption, weight loss, GERD (esophageal reflux), swallowing difficulties, esophageal strictures, peptic ulcer disease, Barrett’s esophagus, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colon polyps and colon cancer, diverticulitis, gastritis, H pylori infections, angioectasias (AVMs), radiation proctitis, pancreatitis and liver abnormalities. Brief Summary of Research activities: 1. Colon cancer pathogenesis and chemoprevention – Our laboratory is focused on the role of diet and signaling pathways that promote or inhibit colon cancer development. These include tumor-promoting Western diets, and inhibitory fish oil diets, growth factor signals and cytokine signals, focusing on ADAM17-EGFR and CXCL12-CXCR4. For these studies, we use animal models, primary human tissue and colonic organoids, and in vitro cell culture models. We are currently carrying out a broad screen of natural products for compounds that inhibit CXCL12-CXCR4 interaction as potential chemopreventive agents for colon cancer. 2. Development of a liquid biopsy (blood test) for colon cancer screening. In collaboration with Dr. Chuan He at the University of Chicago and Dr. Wei Zhang at Northwestern University, we are developing biomarker assays in the blood using 5-hydroxymethylcytosine to diagnose patients with advanced adenomas and early CRC. Similar assays will be used to prognosticate the likelihood of tumor recurrence and assess responses to anti-tumor therapies. 3. Elucidation of the role of Ythdf1 in colon cancer development. Ythdf1 binds N6-methyadenosine (m6A) in mRNA to increase mRNA translation We showed that deletion of Ythdf1 in dendritic cells activated the antigen-specific CD8+ T cell anti-tumor response allowing recognition and killing of colon cancer cells. We are currently studying conditional (LoxP) compound mutant mice with LoxP Ythdf1 and LoxP Apc genes to uncover the role of this m6A mRNA reader in early colonic carcinogenesis. 4. Dissection of the role of the pro-renin receptor (Atp6ap2) in colon cancer. In prior studies we showed that inhibition of the renin-angiotensin system (RAS) is essential for the chemopreventive efficacy of vitamin D to suppress colon tumor development. Vitamin D suppresses renin transcription to reduce RAS signals. AT1 receptor blockade by losartan also suppresses tumor development. The (pro)renin receptor binds renin and catalyzes renin protease activity and induces Wnt signaling. In collaboration with Dr. Yan Chun Li, we are investigating colonic tumorigenesis in mice with conditional deletion of (pro)renin receptor. This deletion (and wild type controls) will be combined with mice expressing a transgene driving renin over-expression.
Education
  • Philadelphia Naval Hospital, Philadelphia, Internship 1976
  • Hospital of the University of Pennsylvania, Residency 1980
  • Hospital of the University of Pennsylvania, Fellowship 1981
  • NIADDK, NIH, Clinical Staff Fellow 1984
  • Univeristy of Chicago , Assistant Professor 1990
  • University of Chicago , Associate Professor
Biosciences Graduate Program Association
Publications

  1. Dougherty U, Mustafi R, Sadiq F, Almoghrabi A, Mustafi D, Kreisheh M, Sundaramurthy S, Liu W, Konda VJ, Pekow J, Khare S, Hart J, Joseph L, Wyrwicz A, Karczmar GS, Li YC, Bissonnette M. The renin-angiotensin system mediates EGF receptor-vitamin d receptor cross-talk in colitis-associated colon cancer. Clin Cancer Res. 2014 Nov 15; 20(22):5848-5859. View in: PubMed

  2. Rajh T, Dimitrijevic NM, Bissonnette M, Koritarov T, Konda V. Titanium dioxide in the service of the biomedical revolution. Chem Rev. 2014 Oct 08; 114(19):10177-216. View in: PubMed

  3. Lu R, Wu S, Zhang YG, Xia Y, Liu X, Zheng Y, Chen H, Schaefer KL, Zhou Z, Bissonnette M, Li L, Sun J. Enteric bacterial protein AvrA promotes colonic tumorigenesis and activates colonic beta-catenin signaling pathway. Oncogenesis. 2014 Jun 09; 3:e105. View in: PubMed

  4. Ueno N, Hasebe T, Kaneko A, Yamamoto M, Fujiya M, Kohgo Y, Kono T, Wang CZ, Yuan CS, Bissonnette M, Chang EB, Musch MW. TU-100 (Daikenchuto) and ginger ameliorate anti-CD3 antibody induced T cell-mediated murine enteritis: microbe-independent effects involving Akt and NF-?B suppression. PLoS One. 2014; 9(5):e97456. View in: PubMed

  5. Wojdyla L, Stone AL, Sethakorn N, Uppada SB, Devito JT, Bissonnette M, Puri N. T-oligo as an anticancer agent in colorectal cancer. Biochem Biophys Res Commun. 2014 Apr 04; 446(2):596-601. View in: PubMed

  6. Pekow J, Bissonnette M. Is RXRa crucially involved in intestinal inflammation? Dig Dis Sci. 2014 Apr; 59(4):702-3. View in: PubMed

  7. Liu W, Chen Y, Golan MA, Annunziata ML, Du J, Dougherty U, Kong J, Musch M, Huang Y, Pekow J, Zheng C, Bissonnette M, Hanauer SB, Li YC. Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis. J Clin Invest. 2013 Sep; 123(9):3983-96. View in: PubMed

  8. Zhang Z, Du GJ, Wang CZ, Wen XD, Calway T, Li Z, He TC, Du W, Bissonnette M, Musch MW, Chang EB, Yuan CS. Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions. Int J Mol Sci. 2013 Jan 31; 14(2):2980-95. View in: PubMed

  9. Pekow J, Dougherty U, Huang Y, Gometz E, Nathanson J, Cohen G, Levy S, Kocherginsky M, Venu N, Westerhoff M, Hart J, Noffsinger AE, Hanauer SB, Hurst RD, Fichera A, Joseph LJ, Liu Q, Bissonnette M. Gene signature distinguishes patients with chronic ulcerative colitis harboring remote neoplastic lesions. Inflamm Bowel Dis. 2013 Mar; 19(3):461-70. View in: PubMed

  10. Konda VJ, Hart J, Lin S, Tretiakova M, Gordon IO, Campbell L, Kulkarni A, Bissonnette M, Seewald S, Waxman I. Evaluation of microvascular density in Barrett's associated neoplasia. Mod Pathol. 2013 Jan; 26(1):125-30. View in: PubMed

  11. Mustafi R, Dougherty U, Shah H, Dehghan H, Gliksberg A, Wu J, Zhu H, Joseph L, Hart J, Dive C, Fichera A, Threadgill D, Bissonnette M. Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts. Carcinogenesis. 2012 Oct; 33(10):1930-9. View in: PubMed

  12. Saleiro D, Murillo G, Benya RV, Bissonnette M, Hart J, Mehta RG. Estrogen receptor-ß protects against colitis-associated neoplasia in mice. Int J Cancer. 2012 Dec 01; 131(11):2553-61. View in: PubMed

  13. Wang CZ, Du GJ, Zhang Z, Wen XD, Calway T, Zhen Z, Musch MW, Bissonnette M, Chang EB, Yuan CS. Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer. Int J Oncol. 2012 Jun; 40(6):1970-6. View in: PubMed

  14. Chen P, Kartha S, Bissonnette M, Hart J, Toback FG. AMP-18 facilitates assembly and stabilization of tight junctions to protect the colonic mucosal barrier. Inflamm Bowel Dis. 2012 Sep; 18(9):1749-59. View in: PubMed

  15. Wang CZ, Kim KE, Du GJ, Qi LW, Wen XD, Li P, Bauer BA, Bissonnette MB, Musch MW, Chang EB, Yuan CS. Ultra-performance liquid chromatography and time-of-flight mass spectrometry analysis of ginsenoside metabolites in human plasma. Am J Chin Med. 2011; 39(6):1161-71. View in: PubMed

  16. Dougherty U, Mustafi R, Wang Y, Musch MW, Wang CZ, Konda VJ, Kulkarni A, Hart J, Dawson G, Kim KE, Yuan CS, Chang EB, Bissonnette M. American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR. BMC Complement Altern Med. 2011 Nov 09; 11:111. View in: PubMed

  17. Chen CC, Pekow J, Llado V, Kanneganti M, Lau CW, Mizoguchi A, Mino-Kenudson M, Bissonnette M, Mizoguchi E. Chitinase 3-like-1 expression in colonic epithelial cells as a potentially novel marker for colitis-associated neoplasia. Am J Pathol. 2011 Sep; 179(3):1494-503. View in: PubMed

  18. Zhu H, Dougherty U, Robinson V, Mustafi R, Pekow J, Kupfer S, Li YC, Hart J, Goss K, Fichera A, Joseph L, Bissonnette M. EGFR signals downregulate tumor suppressors miR-143 and miR-145 in Western diet-promoted murine colon cancer: role of G1 regulators. Mol Cancer Res. 2011 Jul; 9(7):960-75. View in: PubMed

  19. Wang HL, Hart J, Fan L, Mustafi R, Bissonnette M. Upregulation of glycogen synthase kinase 3ß in human colorectal adenocarcinomas correlates with accumulation of CTNNB1. Clin Colorectal Cancer. 2011 Mar 01; 10(1):30-6. View in: PubMed

  20. Pekow JR, Dougherty U, Mustafi R, Zhu H, Kocherginsky M, Rubin DT, Hanauer SB, Hart J, Chang EB, Fichera A, Joseph LJ, Bissonnette M. miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes. Inflamm Bowel Dis. 2012 Jan; 18(1):94-100. View in: PubMed

  21. Zheng W, Wong KE, Zhang Z, Dougherty U, Mustafi R, Kong J, Deb DK, Zheng H, Bissonnette M, Li YC. Inactivation of the vitamin D receptor in APC(min/+) mice reveals a critical role for the vitamin D receptor in intestinal tumor growth. Int J Cancer. 2012 Jan 01; 130(1):10-9. View in: PubMed

  22. Hu S, Dong TS, Dalal SR, Wu F, Bissonnette M, Kwon JH, Chang EB. The microbe-derived short chain fatty acid butyrate targets miRNA-dependent p21 gene expression in human colon cancer. PLoS One. 2011 Jan 20; 6(1):e16221. View in: PubMed

  23. Holgren C, Dougherty U, Edwin F, Cerasi D, Taylor I, Fichera A, Joseph L, Bissonnette M, Khare S. Sprouty-2 controls c-Met expression and metastatic potential of colon cancer cells: sprouty/c-Met upregulation in human colonic adenocarcinomas. Oncogene. 2010 Sep 23; 29(38):5241-53. View in: PubMed

  24. Serfaty L, Bissonnette M, Poupon R. Ursodeoxycholic acid and chemoprevention of colorectal cancer. Gastroenterol Clin Biol. 2010 Oct; 34(10):516-22. View in: PubMed

  25. Mustafi D, Fan X, Dougherty U, Bissonnette M, Karczmar GS, Oto A, Hart J, Markiewicz E, Zamora M. High-resolution magnetic resonance colonography and dynamic contrast-enhanced magnetic resonance imaging in a murine model of colitis. Magn Reson Med. 2010 Apr; 63(4):922-9. View in: PubMed

  26. Dougherty U, Cerasi D, Taylor I, Kocherginsky M, Tekin U, Badal S, Aluri L, Sehdev A, Cerda S, Mustafi R, Delgado J, Joseph L, Zhu H, Hart J, Threadgill D, Fichera A, Bissonnette M. Epidermal growth factor receptor is required for colonic tumor promotion by dietary fat in the azoxymethane/dextran sulfate sodium model: roles of transforming growth factor-{alpha} and PTGS2. Clin Cancer Res. 2009 Nov 15; 15(22):6780-9. View in: PubMed

  27. Hu S, Zhu X, Triggs JR, Tao Y, Wang Y, Lichtenstein L, Bissonnette M, Musch MW, Chang EB. Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis. Am J Physiol Gastrointest Liver Physiol. 2009 May; 296(5):G1003-11. View in: PubMed

  28. Bissonnette ML, Donald JE, DeGrado WF, Jardetzky TS, Lamb RA. Functional analysis of the transmembrane domain in paramyxovirus F protein-mediated membrane fusion. J Mol Biol. 2009 Feb 13; 386(1):14-36. View in: PubMed

  29. Khare S, Chaudhary K, Bissonnette M, Carroll R. Aberrant crypt foci in colon cancer epidemiology. Methods Mol Biol. 2009; 472:373-86. View in: PubMed

  30. Tao Y, Hart J, Lichtenstein L, Joseph LJ, Ciancio MJ, Hu S, Chang EB, Bissonnette M. Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer. Carcinogenesis. 2009 Jan; 30(1):175-82. View in: PubMed

  31. Keswani RN, Chumsangsri A, Mustafi R, Delgado J, Cohen EE, Bissonnette M. Sorafenib inhibits MAPK-mediated proliferation in a Barrett's esophageal adenocarcinoma cell line. Dis Esophagus. 2008; 21(6):514-21. View in: PubMed

  32. Wali RK, Kunte DP, Koetsier JL, Bissonnette M, Roy HK. Polyethylene glycol-mediated colorectal cancer chemoprevention: roles of epidermal growth factor receptor and Snail. Mol Cancer Ther. 2008 Sep; 7(9):3103-11. View in: PubMed

  33. Sun J, Mustafi R, Cerda S, Chumsangsri A, Xia YR, Li YC, Bissonnette M. Lithocholic acid down-regulation of NF-kappaB activity through vitamin D receptor in colonic cancer cells. J Steroid Biochem Mol Biol. 2008 Jul; 111(1-2):37-40. View in: PubMed

  34. Delgado JS, Mustafi R, Yee J, Cerda S, Chumsangsri A, Dougherty U, Lichtenstein L, Fichera A, Bissonnette M. Sorafenib triggers antiproliferative and pro-apoptotic signals in human esophageal adenocarcinoma cells. Dig Dis Sci. 2008 Dec; 53(12):3055-64. View in: PubMed

  35. Khare S, Mustafi R, Cerda S, Yuan W, Jagadeeswaran S, Dougherty U, Tretiakova M, Samarel A, Cohen G, Wang J, Moore C, Wali R, Holgren C, Joseph L, Fichera A, Li YC, Bissonnette M. Ursodeoxycholic acid suppresses Cox-2 expression in colon cancer: roles of Ras, p38, and CCAAT/enhancer-binding protein. Nutr Cancer. 2008; 60(3):389-400. View in: PubMed

  36. Dougherty U, Sehdev A, Cerda S, Mustafi R, Little N, Yuan W, Jagadeeswaran S, Chumsangsri A, Delgado J, Tretiakova M, Joseph L, Hart J, Cohen EE, Aluri L, Fichera A, Bissonnette M. Epidermal growth factor receptor controls flat dysplastic aberrant crypt foci development and colon cancer progression in the rat azoxymethane model. Clin Cancer Res. 2008 Apr 15; 14(8):2253-62. View in: PubMed

  37. Kong J, Zhang Z, Musch MW, Ning G, Sun J, Hart J, Bissonnette M, Li YC. Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G208-16. View in: PubMed

  38. Fichera A, Little N, Dougherty U, Mustafi R, Cerda S, Li YC, Delgado J, Arora A, Campbell LK, Joseph L, Hart J, Noffsinger A, Bissonnette M. A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model. J Surg Res. 2007 Oct; 142(2):239-45. View in: PubMed

  39. Fichera A, Little N, Jagadeeswaran S, Dougherty U, Sehdev A, Mustafi R, Cerda S, Yuan W, Khare S, Tretiakova M, Gong C, Tallerico M, Cohen G, Joseph L, Hart J, Turner JR, Bissonnette M. Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. Cancer Res. 2007 Jan 15; 67(2):827-35. View in: PubMed

  40. Mustafi R, Cerda S, Chumsangsri A, Fichera A, Bissonnette M. Protein Kinase-zeta inhibits collagen I-dependent and anchorage-independent growth and enhances apoptosis of human Caco-2 cells. Mol Cancer Res. 2006 Sep; 4(9):683-94. View in: PubMed

  41. Roy HK, Kunte DP, Koetsier JL, Hart J, Kim YL, Liu Y, Bissonnette M, Goldberg M, Backman V, Wali RK. Chemoprevention of colon carcinogenesis by polyethylene glycol: suppression of epithelial proliferation via modulation of SNAIL/beta-catenin signaling. Mol Cancer Ther. 2006 Aug; 5(8):2060-9. View in: PubMed

  42. Keswani RN, Noffsinger A, Waxman I, Bissonnette M. Clinical use of p53 in Barrett's esophagus. Cancer Epidemiol Biomarkers Prev. 2006 Jul; 15(7):1243-9. View in: PubMed

  43. Cohen G, Mustafi R, Chumsangsri A, Little N, Nathanson J, Cerda S, Jagadeeswaran S, Dougherty U, Joseph L, Hart J, Yerian L, Tretiakova M, Yuan W, Obara P, Khare S, Sinicrope FA, Fichera A, Boss GR, Carroll R, Bissonnette M. Epidermal growth factor receptor signaling is up-regulated in human colonic aberrant crypt foci. Cancer Res. 2006 Jun 01; 66(11):5656-64. View in: PubMed

  44. Bissonnette ML, Connolly SA, Young DF, Randall RE, Paterson RG, Lamb RA. Analysis of the pH requirement for membrane fusion of different isolates of the paramyxovirus parainfluenza virus 5. J Virol. 2006 Mar; 80(6):3071-7. View in: PubMed

  45. Cerda SR, Mustafi R, Little H, Cohen G, Khare S, Moore C, Majumder P, Bissonnette M. Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators. Oncogene. 2006 May 25; 25(22):3123-38. View in: PubMed

  46. Roy HK, Gulizia J, DiBaise JK, Karolski WJ, Ansari S, Madugula M, Hart J, Bissonnette M, Wali RK. Polyethylene glycol inhibits intestinal neoplasia and induces epithelial apoptosis in Apc(min) mice. Cancer Lett. 2004 Nov 08; 215(1):35-42. View in: PubMed

  47. Khare S, Cerda S, Wali RK, von Lintig FC, Tretiakova M, Joseph L, Stoiber D, Cohen G, Nimmagadda K, Hart J, Sitrin MD, Boss GR, Bissonnette M. Ursodeoxycholic acid inhibits Ras mutations, wild-type Ras activation, and cyclooxygenase-2 expression in colon cancer. Cancer Res. 2003 Jul 01; 63(13):3517-23. View in: PubMed

  48. Wali RK, Kong J, Sitrin MD, Bissonnette M, Li YC. Vitamin D receptor is not required for the rapid actions of 1,25-dihydroxyvitamin D3 to increase intracellular calcium and activate protein kinase C in mouse osteoblasts. J Cell Biochem. 2003 Mar 01; 88(4):794-801. View in: PubMed

  49. Wali RK, Khare S, Tretiakova M, Cohen G, Nguyen L, Hart J, Wang J, Wen M, Ramaswamy A, Joseph L, Sitrin M, Brasitus T, Bissonnette M. Ursodeoxycholic acid and F(6)-D(3) inhibit aberrant crypt proliferation in the rat azoxymethane model of colon cancer: roles of cyclin D1 and E-cadherin. Cancer Epidemiol Biomarkers Prev. 2002 Dec; 11(12):1653-62. View in: PubMed

  50. Wali RK, Stoiber D, Nguyen L, Hart J, Sitrin MD, Brasitus T, Bissonnette M. Ursodeoxycholic acid inhibits the initiation and postinitiation phases of azoxymethane-induced colonic tumor development. Cancer Epidemiol Biomarkers Prev. 2002 Nov; 11(11):1316-21. View in: PubMed

  51. Chen A, Davis BH, Sitrin MD, Brasitus TA, Bissonnette M. Transforming growth factor-beta 1 signaling contributes to Caco-2 cell growth inhibition induced by 1,25(OH)(2)D(3). Am J Physiol Gastrointest Liver Physiol. 2002 Oct; 283(4):G864-74. View in: PubMed

  52. Wang HL, Wang J, Xiao SY, Haydon R, Stoiber D, He TC, Bissonnette M, Hart J. Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin. Int J Cancer. 2002 Oct 01; 101(4):301-10. View in: PubMed

  53. Bissonnette MM, Contento IR. Adolescents' perspectives and food choice behaviors in terms of the environmental impacts of food production practices: application of a psychosocial model. J Nutr Educ. 2001 Mar-Apr; 33(2):72-82. View in: PubMed

  54. Cerda SR, Bissonnette M, Scaglione-Sewell B, Lyons MR, Khare S, Mustafi R, Brasitus TA. PKC-delta inhibits anchorage-dependent and -independent growth, enhances differentiation, and increases apoptosis in CaCo-2 cells. Gastroenterology. 2001 Jun; 120(7):1700-12. View in: PubMed

  55. Scaglione-Sewell BA, Bissonnette M, Skarosi S, Abraham C, Brasitus TA. A vitamin D3 analog induces a G1-phase arrest in CaCo-2 cells by inhibiting cdk2 and cdk6: roles of cyclin E, p21Waf1, and p27Kip1. Endocrinology. 2000 Nov; 141(11):3931-9. View in: PubMed

  56. Bissonnette M, Khare S, von Lintig FC, Wali RK, Nguyen L, Zhang Y, Hart J, Skarosi S, Varki N, Boss GR, Brasitus TA. Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1. Cancer Res. 2000 Aug 15; 60(16):4602-9. View in: PubMed

  57. Wali RK, Skarosi S, Hart J, Zhang Y, Dolan ME, Moschel RC, Nguyen L, Mustafi R, Brasitus TA, Bissonnette M. Inhibition of O(6)-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats. Carcinogenesis. 1999 Dec; 20(12):2355-60. View in: PubMed

  58. Chen A, Davis BH, Bissonnette M, Scaglione-Sewell B, Brasitus TA. 1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent Caco-2 cell differentiation. J Biol Chem. 1999 Dec 10; 274(50):35505-13. View in: PubMed

  59. Sitrin MD, Bissonnette M, Bolt MJ, Wali R, Khare S, Scaglione-Sewell B, Skarosi S, Brasitus TA. Rapid effects of 1,25(OH)2 vitamin D3 on signal transduction systems in colonic cells. Steroids. 1999 Jan-Feb; 64(1-2):137-42. View in: PubMed

  60. Khare S, Bissonnette M, Wali R, Skarosi S, Boss GR, von Lintig FC, Scaglione-Sewell B, Sitrin MD, Brasitus TA. 1,25-dihydroxyvitamin D3 but not TPA activates PLD in Caco-2 cells via pp60(c-src) and RhoA. Am J Physiol. 1999 Apr; 276(4 Pt 1):G1005-15. View in: PubMed

  61. Khare S, Bissonnette M, Scaglione-Sewell B, Wali RK, Sitrin MD, Brasitus TA. 1,25-dihydroxyvitamin D3 and TPA activate phospholipase D in Caco-2 cells: role of PKC-alpha. Am J Physiol. 1999 04; 276(4):G993-G1004. View in: PubMed

  62. Bolt MJ, Mailloux RJ, Rasenick MM, Wali RK, Skarosi S, Bissonnette M, Brasitus TA, Sitrin MD. Expression of G protein alpha subunits in normal rat colon and in azoxymethane-induced colonic neoplasms. Gastroenterology. 1998 Dec; 115(6):1494-503. View in: PubMed

  63. Wali RK, Bissonnette M, Skarosi S, Khare S, Sitrin M, Brasitus TA. 1,25-Dihydroxyvitamin D3 targets PKC-betaII but not PKC-alpha to the basolateral plasma membranes of rat colonocytes. Biochem Biophys Res Commun. 1998 Sep 08; 250(1):48-52. View in: PubMed

  64. Brasitus TA, Bissonnette M. PKC isoforms: villains in colon cancer? Gastroenterology. 1998 Jul; 115(1):225-7. View in: PubMed

  65. Scaglione-Sewell B, Abraham C, Bissonnette M, Skarosi SF, Hart J, Davidson NO, Wali RK, Davis BH, Sitrin M, Brasitus TA. Decreased PKC-alpha expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells. Cancer Res. 1998 Mar 01; 58(5):1074-81. View in: PubMed

  66. Abraham C, Scaglione-Sewell B, Skarosi SF, Qin W, Bissonnette M, Brasitus TA. Protein kinase C alpha modulates growth and differentiation in Caco-2 cells. Gastroenterology. 1998 Mar; 114(3):503-9. View in: PubMed

  67. Khare S, Bolt MJ, Wali RK, Skarosi SF, Roy HK, Niedziela S, Scaglione-Sewell B, Aquino B, Abraham C, Sitrin MD, Brasitus TA, Bissonnette M. 1,25 dihydroxyvitamin D3 stimulates phospholipase C-gamma in rat colonocytes: role of c-Src in PLC-gamma activation. J Clin Invest. 1997 Apr 15; 99(8):1831-41. View in: PubMed

  68. Wali RK, Bissonnette M, Khare S, Aquino B, Niedziela S, Sitrin M, Brasitus TA. Protein kinase C isoforms in the chemopreventive effects of a novel vitamin D3 analogue in rat colonic tumorigenesis. Gastroenterology. 1996 Jul; 111(1):118-26. View in: PubMed

  69. Ames EL, Bissonnette M, Acland R, Lister G, Firrell J. Arterial anatomy of the thumb. J Hand Surg Br. 1993 Aug; 18(4):427-36. View in: PubMed

  70. Bolt MJ, Bissonnette BM, Wali RK, Hartmann SC, Brasitus TA, Sitrin MD. Characterization of phosphoinositide-specific phospholipase C in rat colonocyte membranes. Biochem J. 1993 May 15; 292 ( Pt 1):271-6. View in: PubMed

  71. Frawley BP, Tien XY, Hartmann SC, Wali RK, Niedziela SM, Davidson NO, Sitrin MD, Brasitus TA, Bissonnette M. TPA causes divergent responses of Ca(2+)-dependent and Ca(2+)-independent isoforms of PKC in the nuclei of Caco-2 cells. Biochim Biophys Acta. 1994 Jun 30; 1222(2):301-5. View in: PubMed

  72. Khare S, Wilson D, Wali RK, Tien XY, Bissonnette M, Niedziela SM, Bolt MJ, Sitrin MD, Brasitus TA. Guanylin activates rat colonic particulate guanylate cyclase. Biochem Biophys Res Commun. 1994 Sep 30; 203(3):1432-7. View in: PubMed

  73. Khare S, Wilson DM, Tien XY, Wali RK, Bissonnette M, Brasitus TA. Protein kinase C mediates the calcium-induced activation of rat colonic particulate guanylate cyclase. Arch Biochem Biophys. 1994 Oct; 314(1):200-4. View in: PubMed

  74. Bissonnette M, Tien XY, Niedziela SM, Hartmann SC, Frawley BP, Roy HK, Sitrin MD, Perlman RL, Brasitus TA. 1,25(OH)2 vitamin D3 activates PKC-alpha in Caco-2 cells: a mechanism to limit secosteroid-induced rise in [Ca2+]i. Am J Physiol. 1994 Sep; 267(3 Pt 1):G465-75. View in: PubMed

  75. Khare S, Tien XY, Wilson D, Wali RK, Bissonnette BM, Sitrin MD, Brasitus TA. Vitamin D status modulates rat colonic M3 muscarinic receptor characteristics and coupling to guanylate cyclase. FEBS Lett. 1994 Jun 20; 347(1):27-30. View in: PubMed

  76. Khare S, Tien XY, Wilson D, Wali RK, Bissonnette BM, Scaglione-Sewell B, Sitrin MD, Brasitus TA. The role of protein kinase-C alpha in the activation of particulate guanylate cyclase by 1 alpha,25-dihydroxyvitamin D3 in CaCo-2 cells. Endocrinology. 1994 Jul; 135(1):277-83. View in: PubMed

  77. Beno DW, Brady LM, Bissonnette M, Davis BH. Protein kinase C and mitogen-activated protein kinase are required for 1,25-dihydroxyvitamin D3-stimulated Egr induction. J Biol Chem. 1995 Feb 24; 270(8):3642-7. View in: PubMed

  78. Wali RK, Bissonnette M, Jiang K, Niedziela SM, Khare S, Roy HK, Sitrin MD, Brasitus TA. 1,25-Dihydroxyvitamin D3 stimulates the phosphorylation of two acidic membrane proteins of 42,000 and 48,000 daltons in rat colonocytes: an effect modulated by vitamin D status. J Cell Physiol. 1995 Feb; 162(2):172-80. View in: PubMed

  79. Roy HK, Bissonnette M, Frawley BP, Wali RK, Niedziela SM, Earnest D, Brasitus TA. Selective preservation of protein kinase C-zeta in the chemoprevention of azoxymethane-induced colonic tumors by piroxicam. FEBS Lett. 1995 Jun 12; 366(2-3):143-5. View in: PubMed

  80. Bissonnette M, Wali RK, Hartmann SC, Niedziela SM, Roy HK, Tien XY, Sitrin MD, Brasitus TA. 1,25-Dihydroxyvitamin D3 and 12-O-tetradecanoyl phorbol 13-acetate cause differential activation of Ca(2+)-dependent and Ca(2+)-independent isoforms of protein kinase C in rat colonocytes. J Clin Invest. 1995 May; 95(5):2215-21. View in: PubMed

  81. Wali RK, Bissonnette M, Khare S, Hart J, Sitrin MD, Brasitus TA. 1 alpha,25-Dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol, a noncalcemic analogue of 1 alpha,25-dihydroxyvitamin D3, inhibits azoxymethane-induced colonic tumorigenesis. Cancer Res. 1995 Jul 15; 55(14):3050-4. View in: PubMed

  82. Wali RK, Frawley BP, Hartmann S, Roy HK, Khare S, Scaglione-Sewell BA, Earnest DL, Sitrin MD, Brasitus TA, Bissonnette M. Mechanism of action of chemoprotective ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: potential roles of protein kinase C-alpha, -beta II, and -zeta. Cancer Res. 1995 Nov 15; 55(22):5257-64. View in: PubMed

  83. Brasitus TA, Dahiya R, Dudeja PK, Bissonnette BM. Cholesterol modulates alkaline phosphatase activity of rat intestinal microvillus membranes. J Biol Chem. 1988 Jun 25; 263(18):8592-7. View in: PubMed

  84. Werntz JR, Chesher SP, Breidenbach WC, Kleinert HE, Bissonnette MA. A new dynamic splint for postoperative treatment of flexor tendon injury. J Hand Surg Am. 1989 May; 14(3):559-66. View in: PubMed

  85. Bissonnette M, Kuhn D, de Lanerolle P. Purification and characterization of myosin light-chain kinase from the rat pancreas. Biochem J. 1989 Mar 15; 258(3):739-47. View in: PubMed

  86. Plante GE, Bissonnette M, Sirois MG, Regoli D, Sirois P. Renal permeability alteration precedes hypertension and involves bradykinin in the spontaneously hypertensive rat. J Clin Invest. 1992 Jun; 89(6):2030-2. View in: PubMed

  87. Sinicrope FA, Dudeja PK, Bissonnette BM, Safa AR, Brasitus TA. Modulation of P-glycoprotein-mediated drug transport by alterations in lipid fluidity of rat liver canalicular membrane vesicles. J Biol Chem. 1992 Dec 15; 267(35):24995-5002. View in: PubMed
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