Ronald N. Cohen

Education
  • Harvard University , Cambridge, MA, AB Mathematics 06/1987
  • Weill Cornell School of Medicine, New York, NY, MD Medicine 06/1992
  • Beth Israel Hospital, Boston, MA, Internal Medicine Residency 06/1995
  • Beth Israel Deaconess Medical Center, Boston, MA, Endocrinology Fellowship 06/1998
Biosciences Graduate Program Association
Publications
  1. Yang F, Carmona A, Stojkova K, Garcia Huitron EI, Goddi A, Bhushan A, Cohen RN, Brey EM. A 3D human adipose tissue model within a microfluidic device. Lab Chip. 2021 Jan 21; 21(2):435-446. View in: PubMed

  2. Yang F, Cohen RN, Brey EM. Optimization of Co-Culture Conditions for a Human Vascularized Adipose Tissue Model. Bioengineering (Basel). 2020 Sep 17; 7(3). View in: PubMed

  3. Kahn JH, Goddi A, Sharma A, Heiman J, Carmona A, Li Y, Hoffman A, Schoenfelt K, Ye H, Bobe AM, Becker L, Hollenberg AN, Cohen RN. SMRT Regulates Metabolic Homeostasis and Adipose Tissue Macrophage Phenotypes in Tandem. Endocrinology. 2020 10 01; 161(10). View in: PubMed

  4. Szigety KM, Liu F, Yuan CY, Moran DJ, Horrell J, Gochnauer HR, Cohen RN, Katz JP, Kaestner KH, Seykora JT, Tobias JW, Lazar MA, Xu M, Millar SE. HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity. Genes Dev. 2020 07 01; 34(13-14):973-988. View in: PubMed

  5. Nanda R, Liu MC, Yau C, Shatsky R, Pusztai L, Wallace A, Chien AJ, Forero-Torres A, Ellis E, Han H, Clark A, Albain K, Boughey JC, Jaskowiak NT, Elias A, Isaacs C, Kemmer K, Helsten T, Majure M, Stringer-Reasor E, Parker C, Lee MC, Haddad T, Cohen RN, Asare S, Wilson A, Hirst GL, Singhrao R, Steeg K, Asare A, Matthews JB, Berry S, Sanil A, Schwab R, Symmans WF, van 't Veer L, Yee D, DeMichele A, Hylton NM, Melisko M, Perlmutter J, Rugo HS, Berry DA, Esserman LJ. Effect of Pembrolizumab Plus Neoadjuvant Chemotherapy on Pathologic Complete Response in Women With Early-Stage Breast Cancer: An Analysis of the Ongoing Phase 2 Adaptively Randomized I-SPY2 Trial. JAMA Oncol. 2020 05 01; 6(5):676-684. View in: PubMed

  6. White JM, Piron MJ, Rangaraj VR, Hanlon EC, Cohen RN, Brady MJ. Reference Gene Optimization for Circadian Gene Expression Analysis in Human Adipose Tissue. J Biol Rhythms. 2020 02; 35(1):84-97. View in: PubMed

  7. Shimizu H, Lu Y, Vella KR, Damilano F, Astapova I, Amano I, Ritter M, Gallop MR, Rosenzweig AN, Cohen RN, Hollenberg AN. Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action. PLoS One. 2019; 14(8):e0220717. View in: PubMed

  8. Dickens LT, Cifu AS, Cohen RN. Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum Period. JAMA. 2019 May 21; 321(19):1928-1929. View in: PubMed

  9. Casimiro I, Cohen RN. Severe Vasomotor Symptoms Post-Oophorectomy Despite Testosterone Therapy in a Transgender Man: A Unique Case Study. J Endocr Soc. 2019 Apr 01; 3(4):734-736. View in: PubMed

  10. Tanataweethum N, Zelaya A, Yang F, Cohen RN, Brey EM, Bhushan A. Establishment and characterization of a primary murine adipose tissue-chip. Biotechnol Bioeng. 2018 08; 115(8):1979-1987. View in: PubMed

  11. Vaicik MK, Blagajcevic A, Ye H, Morse MC, Yang F, Goddi A, Brey EM, Cohen RN. The Absence of Laminin a4 in Male Mice Results in Enhanced Energy Expenditure and Increased Beige Subcutaneous Adipose Tissue. Endocrinology. 2018 01 01; 159(1):356-367. View in: PubMed

  12. Cohen RN, Davis AM. Management of Adult Patients With Thyroid Nodules and Differentiated Thyroid Cancer. JAMA. 2017 01 24; 317(4):434-435. View in: PubMed

  13. Nanda R, Stringer-Reasor EM, Saha P, Kocherginsky M, Gibson J, Libao B, Hoffman PC, Obeid E, Merkel DE, Khramtsova G, Skor M, Krausz T, Cohen RN, Ratain MJ, Fleming GF, Conzen SD. A randomized phase I trial of nanoparticle albumin-bound paclitaxel with or without mifepristone for advanced breast cancer. Springerplus. 2016; 5(1):947. View in: PubMed

  14. Dickson LM, Gandhi S, Layden BT, Cohen RN, Wicksteed B. Protein kinase A induces UCP1 expression in specific adipose depots to increase energy expenditure and improve metabolic health. . 2016 07 01; 311(1):R79-88. View in: PubMed

  15. Goldfarb Y, Kadouri N, Levi B, Sela A, Herzig Y, Cohen RN, Hollenberg AN, Abramson J. HDAC3 Is a Master Regulator of mTEC Development. Cell Rep. 2016 Apr 19; 15(3):651-665. View in: PubMed

  16. Vaicik MK, Morse M, Blagajcevic A, Rios J, Larson J, Yang F, Cohen RN, Papavasiliou G, Brey EM. Hydrogel-Based Engineering of Beige Adipose Tissue. J Mater Chem B. 2015 Oct 28; 3(40):7903-7911. View in: PubMed

  17. Emont MP, Mantis S, Kahn JH, Landeche M, Han X, Sargis RM, Cohen RN. Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT) regulates glucocorticoid action in adipocytes. Mol Cell Endocrinol. 2015 May 15; 407:52-6. View in: PubMed

  18. Shimizu H, Astapova I, Ye F, Bilban M, Cohen RN, Hollenberg AN. NCoR1 and SMRT play unique roles in thyroid hormone action in vivo. Mol Cell Biol. 2015 Feb; 35(3):555-65. View in: PubMed

  19. Vaicik MK, Thyboll Kortesmaa J, Movérare-Skrtic S, Kortesmaa J, Soininen R, Bergström G, Ohlsson C, Chong LY, Rozell B, Emont M, Cohen RN, Brey EM, Tryggvason K. Laminin a4 deficient mice exhibit decreased capacity for adipose tissue expansion and weight gain. PLoS One. 2014; 9(10):e109854. View in: PubMed

  20. Alikhan M, Koshy A, Hyjek E, Stenson K, Cohen RN, Yeo KT. Discrepant serum and urine ß-hCG results due to production of ß-hCG by a cribriform-morular variant of thyroid papillary carcinoma. Clin Chim Acta. 2015 Jan 01; 438:181-5. View in: PubMed

  21. Bernardi LA, Cohen RN, Stephenson MD. Impact of subclinical hypothyroidism in women with recurrent early pregnancy loss. Fertil Steril. 2013 Nov; 100(5):1326-31. View in: PubMed

  22. Carmean CM, Cohen RN, Brady MJ. Systemic regulation of adipose metabolism. Biochim Biophys Acta. 2014 Mar; 1842(3):424-30. View in: PubMed

  23. Hermanns P, Grasberger H, Cohen R, Freiberg C, Dörr HG, Refetoff S, Pohlenz J. Two cases of thyroid dysgenesis caused by different novel PAX8 mutations in the DNA-binding region: in vitro studies reveal different pathogenic mechanisms. Thyroid. 2013 Jul; 23(7):791-6. View in: PubMed

  24. Markan KR, Jurczak MJ, Allison MB, Ye H, Sutanto MM, Cohen RN, Brady MJ. Enhanced glycogen metabolism in adipose tissue decreases triglyceride mobilization. Am J Physiol Endocrinol Metab. 2010 Jul; 299(1):E117-25. View in: PubMed

  25. Sutanto MM, Ferguson KK, Sakuma H, Ye H, Brady MJ, Cohen RN. The silencing mediator of retinoid and thyroid hormone receptors (SMRT) regulates adipose tissue accumulation and adipocyte insulin sensitivity in vivo. J Biol Chem. 2010 Jun 11; 285(24):18485-95. View in: PubMed

  26. Biyashev D, Veliceasa D, Kwiatek A, Sutanto MM, Cohen RN, Volpert OV. Natural angiogenesis inhibitor signals through Erk5 activation of peroxisome proliferator-activated receptor gamma (PPARgamma). J Biol Chem. 2010 Apr 30; 285(18):13517-24. View in: PubMed

  27. Samarasinghe SP, Sutanto MM, Danos AM, Johnson DN, Brady MJ, Cohen RN. Altering PPARgamma ligand selectivity impairs adipogenesis by thiazolidinediones but not hormonal inducers. Obesity (Silver Spring). 2009 May; 17(5):965-72. View in: PubMed

  28. Yuan W, Pan W, Kong J, Zheng W, Szeto FL, Wong KE, Cohen R, Klopot A, Zhang Z, Li YC. 1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter. J Biol Chem. 2007 Oct 12; 282(41):29821-30. View in: PubMed

  29. Sutanto MM, Symons MS, Cohen RN. SMRT recruitment by PPARgamma is mediated by specific residues located in its carboxy-terminal interacting domain. Mol Cell Endocrinol. 2007 Mar 15; 267(1-2):138-43. View in: PubMed

  30. Kim HH, Wolfe A, Cohen RN, Eames SC, Johnson AL, Wieland CN, Radovick S. In vivo identification of a 107-base pair promoter element mediating neuron-specific expression of mouse gonadotropin-releasing hormone. Mol Endocrinol. 2007 Feb; 21(2):457-71. View in: PubMed

  31. Sutanto MM, Symons MS, Cohen RN. SMRT recruitment by PPARgamma is mediated by specific residues located in its carboxy-terminal interacting domain. Mol Cell Endocrinol. 2006 Oct 19; 259(1-2):43-9. View in: PubMed

  32. Cohen RN. Nuclear receptor corepressors and PPARgamma. Nucl Recept Signal. 2006; 4:e003. View in: PubMed

  33. Wu SY, Cohen RN, Simsek E, Senses DA, Yar NE, Grasberger H, Noel J, Refetoff S, Weiss RE. A novel thyroid hormone receptor-beta mutation that fails to bind nuclear receptor corepressor in a patient as an apparent cause of severe, predominantly pituitary resistance to thyroid hormone. J Clin Endocrinol Metab. 2006 May; 91(5):1887-95. View in: PubMed

  34. Cohen RN, Brue T, Naik K, Houlihan CA, Wondisford FE, Radovick S. The role of CBP/p300 interactions and Pit-1 dimerization in the pathophysiological mechanism of combined pituitary hormone deficiency. J Clin Endocrinol Metab. 2006 Jan; 91(1):239-47. View in: PubMed

  35. Hashimoto K, Cohen RN, Yamada M, Markan KR, Monden T, Satoh T, Mori M, Wondisford FE. Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model. J Biol Chem. 2006 Jan 06; 281(1):295-302. View in: PubMed

  36. Ortiga-Carvalho TM, Shibusawa N, Nikrodhanond A, Oliveira KJ, Machado DS, Liao XH, Cohen RN, Refetoff S, Wondisford FE. Negative regulation by thyroid hormone receptor requires an intact coactivator-binding surface. J Clin Invest. 2005 Sep; 115(9):2517-23. View in: PubMed

  37. Yu C, Markan K, Temple KA, Deplewski D, Brady MJ, Cohen RN. The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis. J Biol Chem. 2005 Apr 08; 280(14):13600-5. View in: PubMed

  38. Lado-Abeal J, Dumitrescu AM, Liao XH, Cohen RN, Pohlenz J, Weiss RE, Lebrethon MC, Verloes A, Refetoff S. A de novo mutation in an already mutant nucleotide of the thyroid hormone receptor beta gene perpetuates resistance to thyroid hormone. J Clin Endocrinol Metab. 2005 Mar; 90(3):1760-7. View in: PubMed

  39. Temple KA, Cohen RN, Wondisford SR, Yu C, Deplewski D, Wondisford FE. An intact DNA-binding domain is not required for peroxisome proliferator-activated receptor gamma (PPARgamma) binding and activation on some PPAR response elements. J Biol Chem. 2005 Feb 04; 280(5):3529-40. View in: PubMed

  40. Ortiga-Carvalho TM, Hashimoto K, Pazos-Moura CC, Geenen D, Cohen R, Lang RM, Wondisford FE. Thyroid hormone resistance in the heart: role of the thyroid hormone receptor beta isoform. Endocrinology. 2004 Apr; 145(4):1625-33. View in: PubMed

  41. Cohen RN, Cohen LE, Botero D, Yu C, Sagar A, Jurkiewicz M, Radovick S. Enhanced repression by HESX1 as a cause of hypopituitarism and septooptic dysplasia. J Clin Endocrinol Metab. 2003 Oct; 88(10):4832-9. View in: PubMed

  42. Shibusawa N, Hashimoto K, Nikrodhanond AA, Liberman MC, Applebury ML, Liao XH, Robbins JT, Refetoff S, Cohen RN, Wondisford FE. Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo. J Clin Invest. 2003 Aug; 112(4):588-97. View in: PubMed

  43. Makowski A, Brzostek S, Cohen RN, Hollenberg AN. Determination of nuclear receptor corepressor interactions with the thyroid hormone receptor. Mol Endocrinol. 2003 Feb; 17(2):273-86. View in: PubMed

  44. Pohlenz J, Dumitrescu A, Zundel D, Martiné U, Schönberger W, Koo E, Weiss RE, Cohen RN, Kimura S, Refetoff S. Partial deficiency of thyroid transcription factor 1 produces predominantly neurological defects in humans and mice. J Clin Invest. 2002 Feb; 109(4):469-73. View in: PubMed

  45. Cohen RN, Brzostek S, Kim B, Chorev M, Wondisford FE, Hollenberg AN. The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains. Mol Endocrinol. 2001 Jul; 15(7):1049-61. View in: PubMed

  46. Hashimoto K, Curty FH, Borges PP, Lee CE, Abel ED, Elmquist JK, Cohen RN, Wondisford FE. An unliganded thyroid hormone receptor causes severe neurological dysfunction. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3998-4003. View in: PubMed

  47. Cohen RN, Putney A, Wondisford FE, Hollenberg AN. The nuclear corepressors recognize distinct nuclear receptor complexes. Mol Endocrinol. 2000 Jun; 14(6):900-14. View in: PubMed

  48. Oberste-Berghaus C, Zanger K, Hashimoto K, Cohen RN, Hollenberg AN, Wondisford FE. Thyroid hormone-independent interaction between the thyroid hormone receptor beta2 amino terminus and coactivators. J Biol Chem. 2000 Jan 21; 275(3):1787-92. View in: PubMed

  49. Safer JD, Cohen RN, Hollenberg AN, Wondisford FE. Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone. J Biol Chem. 1998 Nov 13; 273(46):30175-82. View in: PubMed

  50. Cohen RN, Wondisford FE, Hollenberg AN. Two separate NCoR (nuclear receptor corepressor) interaction domains mediate corepressor action on thyroid hormone response elements. Mol Endocrinol. 1998 Oct; 12(10):1567-81. View in: PubMed

  51. Sgroi D, Cohen RN, Lingenheld EG, Strong MK, Binder T, Goldschneider I, Greiner D, Grunnet M, Clark RB. T cell lines derived from the spinal cords of mice with experimental allergic encephalomyelitis are self reactive. J Immunol. 1986 Sep 15; 137(6):1850-4. View in: PubMed