Ronald N. Cohen

Associate Professor
Education
  • Harvard University , Cambridge, MA, AB Mathematics 06/1987
  • Weill Cornell School of Medicine, New York, NY, MD Medicine 06/1992
  • Beth Israel Hospital, Boston, MA, Internal Medicine Residency 06/1995
  • Beth Israel Deaconess Medical Center, Boston, MA, Endocrinology Fellowship 06/1998
Biosciences Graduate Program Association
Publications
  1. A 3D human adipose tissue model within a microfluidic device. Lab Chip. 2021 01 21; 21(2):435-446. View in: PubMed

  2. Optimization of Co-Culture Conditions for a Human Vascularized Adipose Tissue Model. Bioengineering (Basel). 2020 Sep 17; 7(3). View in: PubMed

  3. SMRT Regulates Metabolic Homeostasis and Adipose Tissue Macrophage Phenotypes in Tandem. Endocrinology. 2020 10 01; 161(10). View in: PubMed

  4. HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity. Genes Dev. 2020 07 01; 34(13-14):973-988. View in: PubMed

  5. Effect of Pembrolizumab Plus Neoadjuvant Chemotherapy on Pathologic Complete Response in Women With Early-Stage Breast Cancer: An Analysis of the Ongoing Phase 2 Adaptively Randomized I-SPY2 Trial. JAMA Oncol. 2020 05 01; 6(5):676-684. View in: PubMed

  6. Reference Gene Optimization for Circadian Gene Expression Analysis in Human Adipose Tissue. J Biol Rhythms. 2020 02; 35(1):84-97. View in: PubMed

  7. Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action. PLoS One. 2019; 14(8):e0220717. View in: PubMed

  8. Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum Period. JAMA. 2019 May 21; 321(19):1928-1929. View in: PubMed

  9. Severe Vasomotor Symptoms Post-Oophorectomy Despite Testosterone Therapy in a Transgender Man: A Unique Case Study. J Endocr Soc. 2019 Apr 01; 3(4):734-736. View in: PubMed

  10. Establishment and characterization of a primary murine adipose tissue-chip. Biotechnol Bioeng. 2018 08; 115(8):1979-1987. View in: PubMed

  11. The Absence of Laminin a4 in Male Mice Results in Enhanced Energy Expenditure and Increased Beige Subcutaneous Adipose Tissue. Endocrinology. 2018 01 01; 159(1):356-367. View in: PubMed

  12. Management of Adult Patients With Thyroid Nodules and Differentiated Thyroid Cancer. JAMA. 2017 01 24; 317(4):434-435. View in: PubMed

  13. A randomized phase I trial of nanoparticle albumin-bound paclitaxel with or without mifepristone for advanced breast cancer. Springerplus. 2016; 5(1):947. View in: PubMed

  14. Protein kinase A induces UCP1 expression in specific adipose depots to increase energy expenditure and improve metabolic health. Am J Physiol Regul Integr Comp Physiol. 2016 07 01; 311(1):R79-88. View in: PubMed

  15. HDAC3 Is a Master Regulator of mTEC Development. Cell Rep. 2016 Apr 19; 15(3):651-665. View in: PubMed

  16. Gender Differences in Cognitive Test Performance in Adults With Heart Failure. J Cardiovasc Nurs. 2017 May/Jun; 32(3):212-217. View in: PubMed

  17. Hydrogel-Based Engineering of Beige Adipose Tissue. J Mater Chem B. 2015 Oct 28; 3(40):7903-7911. View in: PubMed

  18. Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT) regulates glucocorticoid action in adipocytes. Mol Cell Endocrinol. 2015 May 15; 407:52-6. View in: PubMed

  19. NCoR1 and SMRT play unique roles in thyroid hormone action in vivo. Mol Cell Biol. 2015 Feb; 35(3):555-65. View in: PubMed

  20. Laminin a4 deficient mice exhibit decreased capacity for adipose tissue expansion and weight gain. PLoS One. 2014; 9(10):e109854. View in: PubMed

  21. Discrepant serum and urine ?-hCG results due to production of ?-hCG by a cribriform-morular variant of thyroid papillary carcinoma. Clin Chim Acta. 2015 Jan 01; 438:181-5. View in: PubMed

  22. Impact of subclinical hypothyroidism in women with recurrent early pregnancy loss. Fertil Steril. 2013 Nov; 100(5):1326-31. View in: PubMed

  23. Systemic regulation of adipose metabolism. Biochim Biophys Acta. 2014 Mar; 1842(3):424-30. View in: PubMed

  24. Two cases of thyroid dysgenesis caused by different novel PAX8 mutations in the DNA-binding region: in vitro studies reveal different pathogenic mechanisms. Thyroid. 2013 Jul; 23(7):791-6. View in: PubMed

  25. Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies. J Neurovirol. 2011 Aug; 17(4):368-79. View in: PubMed

  26. Enhanced glycogen metabolism in adipose tissue decreases triglyceride mobilization. Am J Physiol Endocrinol Metab. 2010 Jul; 299(1):E117-25. View in: PubMed

  27. The silencing mediator of retinoid and thyroid hormone receptors (SMRT) regulates adipose tissue accumulation and adipocyte insulin sensitivity in vivo. J Biol Chem. 2010 Jun 11; 285(24):18485-95. View in: PubMed

  28. Natural angiogenesis inhibitor signals through Erk5 activation of peroxisome proliferator-activated receptor gamma (PPARgamma). J Biol Chem. 2010 Apr 30; 285(18):13517-24. View in: PubMed

  29. Regional White Matter Signal Abnormalities and Cognitive Correlates Among Geriatric Patients with Treated Cardiovascular Disease. Brain Imaging Behav. 2008 Sep 01; 2(3):200-206. View in: PubMed

  30. Altering PPARgamma ligand selectivity impairs adipogenesis by thiazolidinediones but not hormonal inducers. Obesity (Silver Spring). 2009 May; 17(5):965-72. View in: PubMed

  31. 1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter. J Biol Chem. 2007 Oct 12; 282(41):29821-30. View in: PubMed

  32. SMRT recruitment by PPARgamma is mediated by specific residues located in its carboxy-terminal interacting domain. Mol Cell Endocrinol. 2007 Mar 15; 267(1-2):138-43. View in: PubMed

  33. Lower cardiac output is associated with greater white matter hyperintensities in older adults with cardiovascular disease. J Am Geriatr Soc. 2007 Jul; 55(7):1044-8. View in: PubMed

  34. In vivo identification of a 107-base pair promoter element mediating neuron-specific expression of mouse gonadotropin-releasing hormone. Mol Endocrinol. 2007 Feb; 21(2):457-71. View in: PubMed

  35. SMRT recruitment by PPARgamma is mediated by specific residues located in its carboxy-terminal interacting domain. Mol Cell Endocrinol. 2006 Oct 19; 259(1-2):43-9. View in: PubMed

  36. Nuclear receptor corepressors and PPARgamma. Nucl Recept Signal. 2006; 4:e003. View in: PubMed

  37. A novel thyroid hormone receptor-beta mutation that fails to bind nuclear receptor corepressor in a patient as an apparent cause of severe, predominantly pituitary resistance to thyroid hormone. J Clin Endocrinol Metab. 2006 May; 91(5):1887-95. View in: PubMed

  38. The role of CBP/p300 interactions and Pit-1 dimerization in the pathophysiological mechanism of combined pituitary hormone deficiency. J Clin Endocrinol Metab. 2006 Jan; 91(1):239-47. View in: PubMed

  39. Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model. J Biol Chem. 2006 Jan 06; 281(1):295-302. View in: PubMed

  40. Negative regulation by thyroid hormone receptor requires an intact coactivator-binding surface. J Clin Invest. 2005 Sep; 115(9):2517-23. View in: PubMed

  41. The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis. J Biol Chem. 2005 Apr 08; 280(14):13600-5. View in: PubMed

  42. A de novo mutation in an already mutant nucleotide of the thyroid hormone receptor beta gene perpetuates resistance to thyroid hormone. J Clin Endocrinol Metab. 2005 Mar; 90(3):1760-7. View in: PubMed

  43. An intact DNA-binding domain is not required for peroxisome proliferator-activated receptor gamma (PPARgamma) binding and activation on some PPAR response elements. J Biol Chem. 2005 Feb 04; 280(5):3529-40. View in: PubMed

  44. Thyroid hormone resistance in the heart: role of the thyroid hormone receptor beta isoform. Endocrinology. 2004 Apr; 145(4):1625-33. View in: PubMed

  45. Enhanced repression by HESX1 as a cause of hypopituitarism and septooptic dysplasia. J Clin Endocrinol Metab. 2003 Oct; 88(10):4832-9. View in: PubMed

  46. Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo. J Clin Invest. 2003 Aug; 112(4):588-97. View in: PubMed

  47. Determination of nuclear receptor corepressor interactions with the thyroid hormone receptor. Mol Endocrinol. 2003 Feb; 17(2):273-86. View in: PubMed

  48. Partial deficiency of thyroid transcription factor 1 produces predominantly neurological defects in humans and mice. J Clin Invest. 2002 Feb; 109(4):469-73. View in: PubMed

  49. The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains. Mol Endocrinol. 2001 Jul; 15(7):1049-61. View in: PubMed

  50. An unliganded thyroid hormone receptor causes severe neurological dysfunction. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3998-4003. View in: PubMed

  51. The nuclear corepressors recognize distinct nuclear receptor complexes. Mol Endocrinol. 2000 Jun; 14(6):900-14. View in: PubMed

  52. Thyroid hormone-independent interaction between the thyroid hormone receptor beta2 amino terminus and coactivators. J Biol Chem. 2000 Jan 21; 275(3):1787-92. View in: PubMed

  53. Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone. J Biol Chem. 1998 Nov 13; 273(46):30175-82. View in: PubMed

  54. Two separate NCoR (nuclear receptor corepressor) interaction domains mediate corepressor action on thyroid hormone response elements. Mol Endocrinol. 1998 Oct; 12(10):1567-81. View in: PubMed

  55. T cell lines derived from the spinal cords of mice with experimental allergic encephalomyelitis are self reactive. J Immunol. 1986 Sep 15; 137(6):1850-4. View in: PubMed